✦ LIBER ✦

Parathyroid carcinoma

✍ Scribed by N. Rawat; N. Khetan; D. W. Williams; J. N. Baxter

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 209 KB
Volume: 92
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.5182

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✦ Synopsis

Abstract

Background

Parathyroid carcinoma is a rare malignancy affecting 0·5–5 per cent of all patients with primary hyperparathyroidism. This article reviews the literature on the pathogenesis, pathology, clinical features, diagnosis and management of parathyroid carcinoma.

Methods

A Medline search was performed and all relevant English language articles published between 1970 and 2005 were retrieved. The search words included ‘parathyroid carcinoma’, ‘pathology’, ‘genetics’, ‘management’ and ‘radiotherapy’. Secondary references were obtained from key articles.

Results and conclusion

The exact aetiology of parathyroid carcinoma remains obscure. Recently, the HRPT2 gene has been implicated in its pathogenesis and may prove to be a genetic target in future. Surgical resection is the accepted ‘gold standard’. There is now a growing consensus on the use of adjuvant radiotherapy as it has been shown to provide a survival benefit.

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