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Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

✍ Scribed by Shamsuddin Khwaja; Naganand Sripathi; B.K. Ahmad; Vanda A. Lennon

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 117 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199807)21:7<943::aid-mus14>3.0.co;2-r

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✦ Synopsis

Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti-Yo antibody) was detected in the serum diluted at 1:61,400.

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Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia

✍ Dr. Michael E. Shy; Vance A. Evans; Fred D. Lublin; Robert L. Knobler; Terry Hei 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 464 KB

Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incid