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Parametric investigations of the effects of prior exposure to amphetamine and morphine on conditioned gustatory aversion

✍ Scribed by Howard Cappell; A. E. Blanc

Publisher: Springer
Year: 1977
Tongue: English
Weight: 659 KB
Volume: 51
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431634

No coin nor oath required. For personal study only.

✦ Synopsis

Pretreatment by a psychoactive drug can greatly attenuate the conditioning of gustatory avoidance by that drug. Although such findings have been interpreted in terms of tolerance, alternative explanations are possible. In a series of experiments, it was found that pretreatments with morphine or amphetamine massed at 24-h intervals were no more effective in attenuating conditioning than pretreatments spaced at 120-h intervals, but pretreatment with morphine provided more persistent protection against subsequent conditioning by itself than did amphetamine in a comparable previous experiment. The similarity of massed and spaced pretreatment effects can be interpreted without appealing to tolerance as a factor, but the greater persistence of morphine pretreatment implicates tolerance as a mechanism.

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