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The effects of prior exposure to bleomycin on the incidence of pulmonary toxicities in a group of patients with disseminated testicular carcinomas

โœ Scribed by Crooke, Stanley T. ;Einhorn, Lawrence H. ;Comis, Robert L. ;D'Aoust, Joan C. ;Prestayko, Archie W.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
338 KB
Volume
5
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

The incidence of pulmonary toxicities in 12 patients with prior exposure to bleomycin (BLM) was compared to the incidence of pulmonary toxicities in a matched group of 73 patients with state II or IV testicular carcinomas treated with a regimen containing vinblastine, bleomycin, and cis-diamminedichloroplatinum. The comparison demonstrates that prior exposure to bleomycin constitutes a significant risk factor and that the risk is additive; ie, prior doses should be added to current doses to determine the cumulative dose-related probablity of development of pulmonary toxicities.

๐Ÿ“œ SIMILAR VOLUMES

Bleomycin-induced pulmonary fibrosis mim
Bleomycin-induced pulmonary fibrosis mimicking recurrent metastatic disease in a patient with testicular carcinoma: Case report of the CT scan appearance
โœ James B. Nachman; Edward S. Baum; Harvey White; Frank G. Cruissi ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 509 KB

Pulmonary fibrosis is a well-recognized complication of bleomycin therapy. Detection of bleomycin-induced pulmonary fibrosis by computed axial tomographic scanning (CT) has not been reported. We report on a patient in whom the development of lesions on chest CT scan following cessation of chemothera