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Parallels and distinctions between T and NKT cell development in the thymus

โœ Scribed by Berzins, Stuart P; Uldrich, Adam P; Pellicci, Daniel G; McNab, Finlay; Hayakawa, Yoshihiro; Smyth, Mark J; Godfrey, Dale I

Book ID
110754354
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
256 KB
Volume
82
Category
Article
ISSN
0818-9641

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Thymic development proceeds through several defined stages that generate not only ab and gd T cells but can produce dendritic cells and B cells. The earliest thymocytes exist in the CD4 ร€ CD8 ร€ double negative compartment within a heterogeneous fraction termed DN1. Recent progress has identified sev