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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter p ylori Dihydroorotate Dehydrogenase

✍ Scribed by Haque, Tasir S.; Tadesse, Seifu; Marcinkeviciene, Jovita; Rogers, M. John; Sizemore, Christine; Kopcho, Lisa M.; Amsler, Karen; Ecret, Lisa D.; Zhan, Dong Liang; Hobbs, Frank; Slee, Andrew; Trainor, George L.; Stern, Andrew M.; Copeland, Robert A.; Combs, Andrew P.


Book ID
121206713
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
266 KB
Volume
45
Category
Article
ISSN
0022-2623

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The synthesis of potentially selective i
✍ Amanda E Sutton; Jon Clardy πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 101 KB

A series of potentially selective inhibitors of dihydroorotate dehydrogenase (DHODH) were synthesized via iterative, chemoselective Suzuki cross-couplings utilizing biaryl chlorides as key intermediates.