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Parallel synthesis of polysubstituted tetrahydroquinolines

✍ Scribed by Romuald Baudelle; Patricia Melnyk; Benoît Déprez; André Tartar


Book ID
108378953
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
641 KB
Volume
54
Category
Article
ISSN
0040-4020

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Solid support synthesis of polysubstitut
✍ Alexander S. Kiselyov; Leon Smith II; Robert W. Armstrong 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 469 KB

Solid support synthesis of polysubstituted tetrahydroquinolines is described. The procedure is based on a three-component condensation involving immobilized derivatives of 4-aminophenylalanine, aldehydes, alkenes and Yb(OTf) 3 as a catalyst. The methodology is further expanded to the solid support s