## Abstract The reaction proceeds with the highest diastereoselectivity for orthoβsubstituted aromatic imine substrates [cf.
Highly Enantioselective Synthesis of Polysubstituted Tetrahydroquinolines via Organocatalytic Michael/Aza-Henry Tandem Reactions
β Scribed by Jia, Zhen-Xin; Luo, Yong-Chun; Xu, Peng-Fei
- Book ID
- 120704722
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 699 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
Enantioenriched tetrasubstituted thiochromanes have been synthesized using a tandem Michael addition-Knoevenagel reaction between 2-mercaptobenzaldehydes and benzylidenemalonates with a 9-epi-aminoquinine thiourea derivative as the catalyst. Steric and electron effects were found to affect profoundl
An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the catalyst was developed. Michael adducts (R)-24 and (R)-27 were isolated in good yield and high ee and