Parallel synthesis of 4-amino-2,6-dialkylamino-pyridines

✍ Scribed by Maria Menichincheri; Domenico Fusar Bassini; Markus Gude; Mauro Angiolini

• Book ID: 104252686
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 185 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02585-6

✦ Synopsis

In this letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesized respectively in two or three steps in good yields. The method described is mild, adaptable to combinatorial purposes and applicable to a variety of amines.