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Parallel synthesis and biological activity of a new class of high affinity and selective δ-opioid ligand

✍ Scribed by D.R. Barn; W.L. Caulfield; J. Cottney; K. McGurk; J.R. Morphy; Z. Rankovic; B. Roberts


Book ID
108479054
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
554 KB
Volume
9
Category
Article
ISSN
0968-0896

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The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'l°.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'l°.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind