Paragangliomas in patients with mutations of the SDHD gene
✍ Scribed by Carsten Christof Boedeker; Hartmut P.H. Neumann; Gerd Jürgen Ridder; Wolfgang Maier; Jörg Schipper
- Book ID
- 116810200
- Publisher
- SAGE Publications
- Year
- 2005
- Tongue
- English
- Weight
- 201 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0194-5998
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## Abstract Paraganglioma (PGL) is a rare disorder characterized by tumors of the head and neck region. Between 10% and 50% of cases of PGL are familial, and the disease is autosomal dominant and subject to age‐dependent penetrance and imprinting. The paraganglioma gene (__PGL1__) has been mapped t
## Abstract Hereditary paragangliomas or glomus tumors are usually benign slow‐growing tumors in the head and neck region. The inheritance pattern of hereditary paraganglioma is autosomal dominant with imprinting. Recently, we have identified the __SDHD__ gene encoding subunit D of the mitochondria