✦ LIBER ✦

Paraganglioma of the thyroid: Two cases that clarify and expand the clinical spectrum

✍ Scribed by Joseph D. Kronz; Pedram Argani; Robert Udelsman; Lawrence Silverberg; William H. Westra

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 249 KB
Volume: 22
Category: Article
ISSN: 1043-3074
DOI: 10.1002/1097-0347(200009)22:6<621::aid-hed12>3.0.co;2-h

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✦ Synopsis

Background:

Paragangliomas (pgs) can, on rare occasions, arise within the thyroid parenchyma presumably from displaced laryngeal paraganglia. on the basis of a limited number of reported cases, thyroid pgs invariably affect women, they are always benign, and they are usually mistaken for some other more common thyroid lesion.

Methods:

We describe the histopathologic features, immunohistochemical findings, and clinical characteristics of two thyroid pgs.

Results:

One tumor was incidentally discovered in a 55-year-old man during evaluation of a carotid bruit. the other tumor aggressively invaded the trachea and esophagus of a 52-year-old woman with a presumed long-standing nodular goiter. in both cases, the initial pathologic evaluation suggested medullary thyroid carcinoma. both patients are alive without recurrent disease after surgical resection.

Conclusions:

These cases emphasize the need to consider pg in the differential diagnosis of neuroendocrine thyroid tumors, even in those tumors involving men or behaving in a locally aggressive fashion. failure to do so carries grave implications regarding patient prognosis and management.

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