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PAR-2-mediated endothelial cell activation induces leukocyte transmigration through endothelial monolayers

✍ Scribed by Vliagoftis, Harissios; Ebeling, Cory; Kennedy, John A; Wright, Clifford D


Book ID
119490493
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
158 KB
Volume
109
Category
Article
ISSN
1097-6825

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## Abstract Sphingosylphosphorylcholine (SPC) produces reactive oxygen species (ROS) in MS1 pancreatic islet endothelial cells. In the present study, we explored the physiological significance of the SPC‐induced ROS generation in endothelial cells. SPC induced cell death of MS1 cells at higher than