Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer
✍ Scribed by Douillard, Jean-Yves; Oliner, Kelly S.; Siena, Salvatore; Tabernero, Josep; Burkes, Ronald; Barugel, Mario; Humblet, Yves; Bodoky, Gyorgy; Cunningham, David; Jassem, Jacek; Rivera, Fernando; Kocákova, Ilona; Ruff, Paul; Błasińska-Morawiec, Maria; Šmakal, Martin; Canon, Jean Luc; Rother, Mark; Williams, Richard; Rong, Alan; Wiezorek, Jeffrey; Sidhu, Roger; Patterson, Scott D.
- Book ID
- 125488433
- Publisher
- Massachusetts Medical Society
- Year
- 2013
- Tongue
- English
- Weight
- 876 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0096-6762
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Background: Identifying predictive biomarkers is important to optimally treat patients. This analysis evaluated the association of K-ras, BRAF, and PIK3CA gene mutations with tumor resistance to panitumumab alone. Patients and Methods: From 3 phase II panitumumab metastatic colorectal cancer (mCRC)