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Palladium/Copper (I) halide-cocatalyzed stereospecific coupling of 1-fluorovinylstannanes with aryl iodides and acyl chlorides

โœ Scribed by Chen Chen; Keith Wilcoxen; Kyung-il Kim; James R. McCarthy


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
221 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Cross-coupling of 1-fluorovinylstannanes with aryl iodides or acyl chlorides, cocatalyzed by palladium and copper (I) iodide proceeded under mild conditions to give substituted fluoro oleflns and ot-fluoro-ct,~-unsaturated ketones, respectively, in good yields with retention of configuration.


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Palladium/copper (I) halide catalyzed cross couplings of (E)-and (Z)-I,2difluorovinyistannanes with aryl iodides and vinyl halides proceeded at room temperature to stereospecifically give 1,2-disubstituted-l,2-difluoroolef'ms and 1,2difluoro or 1,2,3,4-tetrafluorosubstituted dienes in good to excell