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Palladium(0)-catalyzed tandem cyclization of N-(2′,4′-dienyl)alkynamides to α-alkylidene-γ-lactams

✍ Scribed by Xu Xie; Xiyan Lu


Book ID
104262376
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
185 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis


~-Alkylidene-y-lactams were synthesized from N-(2'A'-dienyl)aikynamides via Pd(0)-catalyzed reactions in moderate to good yields.


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Palladium(II)-catalyzed cyclization of W
✍ Xa He; H-Yan Lu; Guo-Sheng Liu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 1 views

## Abstract In the presence of CuCl~2~, __N‐__(2′, 4′‐dienyl)‐2‐alkynamides can be converted to α‐alkylidene‐σ‐butyrolactams under the catalysis of palladium(II). In this reaction, CuCl~2~ is used to oxidize Pd(0) to regenerate Pd(II), or the carbon‐palladium bond is quenched by the oxidative cleav