✦ LIBER ✦

Palladium(II)-catalyzed cyclization of W-(2′,4′-dienyl)-2-alkynamides to α-alkylidene-γ-butyrolactams

✍ Scribed by Xa He; H-Yan Lu; Guo-Sheng Liu

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 270 KB
Volume: 19
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.20010191221

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✦ Synopsis

Abstract

In the presence of CuCl~2~, N‐(2′, 4′‐dienyl)‐2‐alkynamides can be converted to α‐alkylidene‐σ‐butyrolactams under the catalysis of palladium(II). In this reaction, CuCl~2~ is used to oxidize Pd(0) to regenerate Pd(II), or the carbon‐palladium bond is quenched by the oxidative cleavage reaction of CuCl~2~.

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