Palladium-Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)-α-Kainic Acid

✍ Scribed by Dr. Martin A. Lowe; Dr. Mehrnoosh Ostovar; Dr. Serena Ferrini; C. Chun Chen; Paul G. Lawrence; Dr. Francesco Fontana; Dr. Andrew A. Calabrese; Prof. Varinder K. Aggarwal

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 397 KB
• Volume: 50
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.201101389

✦ Synopsis

Scheme 1. Palladium-catalyzed annulation reaction of vinyl epoxides/ aziridines with Michael acceptors. EWG = electron-withdrawing group, Ts = 4-toluenesulfonyl. Scheme 2. Possible origin of low reactivity of amide towards MVK.