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Palladium-Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)-α-Kainic Acid

✍ Scribed by Dr. Martin A. Lowe; Dr. Mehrnoosh Ostovar; Dr. Serena Ferrini; C. Chun Chen; Paul G. Lawrence; Dr. Francesco Fontana; Dr. Andrew A. Calabrese; Prof. Varinder K. Aggarwal


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
408 KB
Volume
123
Category
Article
ISSN
0044-8249

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Palladium-Mediated Annulation of Vinyl A
✍ Dr. Martin A. Lowe; Dr. Mehrnoosh Ostovar; Dr. Serena Ferrini; C. Chun Chen; Pau 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB 👁 1 views

Scheme 1. Palladium-catalyzed annulation reaction of vinyl epoxides/ aziridines with Michael acceptors. EWG = electron-withdrawing group, Ts = 4-toluenesulfonyl. Scheme 2. Possible origin of low reactivity of amide towards MVK.