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Palladium-catalyzed multiple arylation of phenyl ketones with aryl bromides

โœ Scribed by Tetsuya Satoh; Yoko Kametani; Yoshito Terao; Masahiro Miura; Masakatsu Nomura

Book ID
104261756
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
225 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Benzyl phenyl ketones undergo triarylation upon treatment with excess aryl bromides in the presence of a catalytic mount of Pd(PPh3) 4 and Cs2CO 3 as base in o-xylene on the ct-and two ortho-positions of the carbonyl group to give diphenymethyl 2,6-diphenylphenyl ketone derivatives as the predominant products. Acetophenone and diphenylmethyl phenyl ketone similarly undergo tetra-and diarylations, respectively.

๐Ÿ“œ SIMILAR VOLUMES

Palladium-catalyzed ฮฑ-arylation of aldeh
Palladium-catalyzed ฮฑ-arylation of aldehydes with aryl bromides
โœ Yoshito Terao; Yuichi Fukuoka; Tetsuya Satoh; Masahiro Miura; Masakatsu Nomura ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 89 KB

Aliphatic linear and a-branched aldehydes efficiently undergo arylation at the a-position upon treatment with aryl bromides using an appropriate palladium catalyst system that is capable of overcoming aldol condensation of the substrates.