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Palladium-catalyzed heteroannulation of internal alkynes by vinylic halides

โœ Scribed by Richard C. Larock; Mark J. Doty; Xiaojun Han

Book ID
104259483
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
252 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A number of heterocycles have been synthesized regioselectively in good yields by treating appropriate functionally-substituted vinylic halides with internal alkynes in the presence of a palladium catalyst.

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Synthesis of 5-, 6- and 7-azaindoles via
Synthesis of 5-, 6- and 7-azaindoles via palladium-catalyzed heteroannulation of internal alkynes
โœ Feroze Ujjainwalla; Daniel Warner ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 214 KB

The palladium-catalyzed heteroannulation of internal alkynes using orthoaminoiodopyridine derivatives is described. This experimentally simple procedure, which employs a Pd(dppf)C12/LiCl/Na~CO 3 reagent system, allows rapid and reliable access to a structurally diverse range of 5-, 6-and 7-azaindole