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Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives

✍ Scribed by Feng, Zhang; Min, Qiao-Qiao; Xiao, Yu-Lan; Zhang, Bo; Zhang, Xingang


Book ID
125483206
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
653 KB
Volume
126
Category
Article
ISSN
0044-8249

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The cross-coupling reaction of acid chlorides with arylboronic acids, using catalytic amounts of Pd(PPh3)4 and five equivalents Cs2CO3, under anhydrous conditions provides a new method for the synthesis of ketones in good to moderate yields.