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Palladium-Catalyzed Decarboxylative Rearrangements of Allyl 2,2,2-Trifluoroethyl Malonates: Direct Access to Homoallylic Esters

✍ Scribed by Tardibono, Lawrence P.; Patzner, Jerod; Cesario, Cara; Miller, Marvin J.


Book ID
127257888
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
320 KB
Volume
11
Category
Article
ISSN
1523-7060

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Palladium-catalyzed double allylic alkyl
✍ Sébastien Laliberté; Peter K. Dornan; Austin Chen 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 408 KB

The synthesis of pyrazino[1,2-a]indoles via a palladium-catalyzed double allylic alkylation of indole-2hydroxamates is described. The reaction conditions are very mild and allow for a wide variety of substitutions on the indole core.