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Palladium-catalyzed double allylic alkylation of indole-2-hydroxamates: easy access to pyrazino[1,2-a]indole derivatives

✍ Scribed by Sébastien Laliberté; Peter K. Dornan; Austin Chen

Book ID: 104097146
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 408 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.11.031

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✦ Synopsis

The synthesis of pyrazino[1,2-a]indoles via a palladium-catalyzed double allylic alkylation of indole-2hydroxamates is described. The reaction conditions are very mild and allow for a wide variety of substitutions on the indole core.

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