Palladium-catalyzed cascade cyclization-coupling reactions of 2-bromo-1,6-enynes with organoboronic acids

✍ Scribed by Chang Ho Oh; Young Mook Lim

• Book ID: 104252647
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 257 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02536-4

✦ Synopsis

2-Bromo-1,6-enynes 5 with a palladium catalyst would form the alkenylpalladium intermediates via an intramolecular Heck reaction, which were cross-coupled with various organoboronic acids 8 to give the cyclization-coupling products 6 in synthetically valuable yields.