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Palladium-catalyzed, carbonylative, intramolecular coupling of hydroxyvinyl triflates. Synthesis of substituted .alpha.,.beta.-butenolides

โœ Scribed by Crisp, Geoffrey T.; Meyer, Adam G.


Book ID
115484640
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
579 KB
Volume
57
Category
Article
ISSN
0022-3263

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Intramolecular palladium catalyzed alkox
โœ James D. White; Jian Hong; Lonnie A. Robarge ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 184 KB

The reaction of hydroxy alkenes 5, 7, and 8 with CO and MeOH in the presence of PdCI 2 and CuCI 2 gave tetrahydropyrans 9, 11, and 12, respectively. Yields were dependent upon the configuration of substituents in the hydroxy alkene; in all cases, the tetrahydropyran was produced with 2,6-cis configu