Palladium-Catalyzed Annulation of 2-(1-Alkynyl)biphenyls with Aryl Iodides to Disubstituted Methylidenefluorenes
β Scribed by Chen, Chin-Chau; Yang, Shyh-Chyun; Wu, Ming-Jung
- Book ID
- 127374683
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 543 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The reaction of 1-alkynylcyclobutanols with aryl iodides in the presence of Pd(OAc) 2 and Et 3 N in acetonitrile at 80Β°C for 24 h gives 2-disubstituted methylenecyclopentan-1-ones in modest to good yields. The tandem insertion-ring expansion process proceeds via the formation of an alkynyl p-complex
## Abstract 3βSulfenylindoles can be efficiently prepared in moderate to good yields from 2β(1βalkynyl)benzenamines and disulfides using the palladium/air catalytic systems. The study also provides a useful route to the synthesis of fipronil analogues.