Pakistolides A and B, Novel Enzyme Inhibitory and Antioxidant Dimeric 4-(Glucosyloxy)Benzoates from Berchemia pakistanica

✍ Scribed by Naveen Mukhtar; Abdul Malik; Naheed Riaz; Kiran Iqbal; Rasool Bakhsh Tareen; Shamsun Nahar Khan; Sarfraz Ahmad Nawaz; Juveria Siddiqui; M. Iqbal Choudhary

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 156 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490040

✦ Synopsis

Abstract

Pakistolides A and B, novel dimeric β‐(glucosyloxy)benzoates were isolated from Berchemia pakistanica and assigned structures 1 and 2 on the basis of extensive NMR studies. In addition, the known compounds 7,5′‐dimethoxy‐3,5,2′‐trihydroxyflavone (=3,5‐dihydroxy‐2‐(2‐hydroxy‐5‐methoxyphenyl)‐7‐methoxy‐4__H__‐1‐benzopyran‐4‐one), 4′,5‐dihydroxy‐3,6,7‐trimethoxyflavone (=5‐hydroxy‐2‐(4‐hydroxyphenyl)‐3,6,7‐trimethoxy‐4__H__‐1‐benzopyran‐4‐one), 5,6‐dihydroxy‐4,7‐dimethoxy‐2‐methylanthracene‐9,10‐dione, and 1,3,4‐trihydroxy‐6,7,8‐trimethoxy‐2‐methylanthracene‐9,10‐dione were reported for the first time from the genus Berchemia. Both 1 and 2 showed significant α‐glucosidase and lipoxygenase inhibitory activities, while 2 also showed antioxidant potential.