Berchemins A and B: Novel Enzyme-Inhibiting Dimeric Lignan Glycosides from Berchemia pakistanica

✍ Scribed by Naveen Mukhtar; Abdul Malik; Kiran Iqbal; Rasool Bakhsh Tareen; Shamsun Nahar Khan; Sarfraz Ahmad Nawaz; M. Iqbal Choudhary

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 121 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490183

✦ Synopsis

Abstract

Phytochemical investigation of Berchemia pakistanica by extensive bioassay‐guided fractionation resulted in the isolation of two novel dimeric lignan glycosides, berchemin A (1) and berchemin B (2), and of the four known compounds β‐sitosterol, β‐sitosterol 3‐O‐β‐D‐glucoside, vavain, and daphnetin 8‐β‐D‐glucoside. The structures of 1 and 2 were elucidated with the help of modern spectroscopic techniques, and the known compounds were identified by comparing their spectral data with those reported in the literature. Berchemins A and B were found to inhibit lipoxygenase and α‐glucosidase enzymes in a concentration‐dependent fashion.