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Paired helical filaments (PHF) and abnormally phosphorylated tau

โœ Scribed by Ihara, Yasuo; Hasegawa, Masato; Morishima, Maho; Takio, Koji


Book ID
122742864
Publisher
Elsevier Science
Year
1991
Weight
88 KB
Volume
16
Category
Article
ISSN
0921-8696

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Paired helical filaments (PHFs) purified from Alzheimer's brain consist of hyperphosphorylated microtubule-associated protein tau. In PHF, phosphorylation occurs at ser/thr tau residues. Several of these ser/thr phosphorylation sites lie immediately C-terminal to the tau tubulin binding domain. The