Paired helical filament (PHF) proteins are encoded by exon 1 of tau gene
โ Scribed by Tejera, Carlos A.; Saravay, Stephen M.; Goldman, Eliot; Gluck, Lori
- Book ID
- 122406662
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 151 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0197-4580
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Paired helical filaments (PHFs) purified from Alzheimer's brain consist of hyperphosphorylated microtubule-associated protein tau. In PHF, phosphorylation occurs at ser/thr tau residues. Several of these ser/thr phosphorylation sites lie immediately C-terminal to the tau tubulin binding domain. The
Neuron-like cells derived from a rat pheochromocytoma cell line (PC12) and differentiated with nerve growth factor produce a paired helical filament (PHF)like antigen when they are subjected to heat shock (Wallace et al.: Mol Brain Res 19:149-155, 1993). It accumulates in a localized region of the p