Paget's disease primarily involving the scrotum
β Scribed by Manuel A. Perez; Donato D. Larossa; John E. Tomaszewski
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 786 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
Three cases of Paget's disease primarily involving the scrotum are reported. One case exhibited positive staining for prostate specific antigen (PSA) and was associated with an underlying, invasive poorly differentiated adenocarcinoma of unknown primary. The other cases were not associated with any underlying or visceral malignancy. The literature on Paget's disease primarily involving the scrotum including clinical presentation, differential diagnosis, treatment, prognosis, and possible histogenetic mechanisms of this disease is discussed.
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A 75-year-old man with carcinoma of the prostate presented with a pruritic, erythematous plaque involving the scrotal skin. Histological examination revealed extramammary Paget's disease. The intraepidermal tumour cells expressed prostate-specific antigen in keeping with a prostatic origin.