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Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism

✍ Scribed by Greenberg, Victoria L; Zimmer, Stephen G


Book ID
110069675
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
330 KB
Volume
24
Category
Article
ISSN
0950-9232

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Increased phosphorylation of the translational repressor protein 4E-BP1 was found in the cell line derived from the tumor induced in Syrian hamster by Rous sarcoma virus (RSV). This was accompanied by its dissociation from the complex with initiation factor eIF4E. The ribosomal S6 protein kinase p70