## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi
Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck. A phase II trial
β Scribed by Marco Merlano; Elvio G. Russi; Gianmauro Numico; Ida Colantonio; Ornella Garrone; Antonio Pelissero; Cristina Granetto; Milena Gasco; Gianna Di Costanzo; Abdelhamid Heouaine; Riccardo Vigna Taglianti; Marco Cipolat
- Book ID
- 118496394
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 64 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0167-8140
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## Abstract ## BACKGROUND The current study evaluated the feasibility and clinical activity of a combination of paclitaxel, cisplatin, 5βfluorouracil (5βFU), and leucovorin administered on a biweekly schedule to patients with recurrent or unresectable squamous cell carcinoma of the head and neck (
Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt