Paclitaxel and cisplatin in patients with recurrent and metastatic head and neck squamous cell carcinoma
β Scribed by Vincenzo Adamo; Giuseppa Ferraro; Stefano Pergolizzi; Concetta Sergi; Agata Laudani; Nicola Settineri; Elisabetta Alafaci; Antonino Scimone; Franca Spano; Gianluca Spitaleri
- Book ID
- 113832360
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 180 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1368-8375
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi
Forty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with vinblastine, bleomycin, and cisplatin. All patients had received prior surgery, radiation or chemotherapy and all had measurable disease. Forty-five percent of the patients responded with a
## Abstract ## Objective. We assessed the response rate and the toxicity of cisplatin plus vinorelbine in patients with this condition. ## Patients and Method. Fortyβtwo patients were included. Therapy consisted of cisplatin, 100 mg/m^2^ on day 1, and vinorelbine, 25 mg/m^2^ on days 1 and 8, giv