Pachymoside A — A Novel Glycolipid Isolated from the Marine Sponge Pachymatisma johnstonia.
✍ Scribed by Kaoru Warabi; William T. Zimmerman; Jingkai Shen; Annick Gauthier; Marilyn Robertson; B. Brett Finlay; Rob van Soest; Raymond J. Andersen
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 60 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A high anti‐leishmanial activity was observed in an aqueous extract from the marine sponge__Pachymatisma johnstonii__, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical‐like am
We use the chamigrene numbering for the structural formulae and spectroscopic data; IUPAC nomenclature and numbering are used for retrieval purposes. ' ) 4, The structural assignment of (-)-5 rests on the enone UV absorption at 1 , , , 325 and 240 nm and on NMR data for two conformers resulting from