✦ LIBER ✦
A GLYCOPROTEIN ISOLATED FROM THE SPONGE, PACHYMATISMA JOHNSTONII, HAS ANTI-LEISHMANIAL ACTIVITY
✍ Scribed by Patrice Le Pape; Mohamed Zidane; Hiam Abdala; Marie-Thérèse Moré
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 556 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
Abstract
A high anti‐leishmanial activity was observed in an aqueous extract from the marine sponge__Pachymatisma johnstonii__, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical‐like amastigote stages with IC~50~about 1μg protein/ml and induces changes in the cell shape, phospholipase A~2~activity and invasion capacity of the parasite. We believe pachymatismin is the first reported substance from a marine organism with anti‐leishmanial activity.