PACBERG: An adaptive program for controlling the blood sugar

✍ Scribed by Giovanni Pacini; Richard N Bergman

• Publisher: Elsevier Science
• Year: 1983
• Weight: 505 KB
• Volume: 16
• Category: Article
• ISSN: 0010-468X
• DOI: 10.1016/0010-468x(83)90003-x

✦ Synopsis

PACBERG, a new computer program for automatically controlling (clamping) the blood sugar is described. The plasma glucose concentration is maintained at steady basal (euglycemic) or elevated (hyperglycemic) levels during various insulin infusions. To accomplish this, a minimal mathematical model of glucose kinetics is implemented on a minicomputer. From the measured time course of plasma glucose concentration, using the model, the program estimates the insulin-dependent increase in fractional disappearance rate of glucose (X). In addition the program calculates the rate of exogenous glucose infusion (1NF) which must be infused in order to maintain the desired glucose concentration. The program successfully clamps glucose at desired basal or elevated levels. Furthermore, the variable X, provided as the PACBERG studies proceed, is a real-time measure of insulin action which can be used to calculate insulin sensitivity ($I). PACBERG was written in BASIC, but can also be implemented on programmable calculators.

Glucose clamp

Minimal modeling Adaptive control Insulin sensitivity