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P89: Antitumor effects of apigenin alone and in combination with gemcitabine via PI3/Akt pathway inhibition in pancreatic cancer cells

✍ Scribed by J.J. McGill; L. Golkar; M.R. Salabat; M.B. Ujiki; B. Milam; D.M. Hieferman; J.C. Pelling; M.S. Talamonti; D.J. Bentrem

Book ID: 116703128
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 113 KB
Volume: 137
Category: Article
ISSN: 0022-4804
DOI: 10.1016/j.jss.2006.12.318

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## Abstract HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras‐dependent signaling induced by