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Impact of AKT/PI3K signaling pathway in pancreatic cancer and synergistic interaction of the novel Akt inhibitor perifosine with gemcitabine in pancreatic cancer cells

✍ Scribed by Avan, Amir; Maftouh, Mina; Funel, Niccola; Raktoe, Rajiv; van Krieken, Anne; Peters, Godefridus; Giovannetti, Elisa

Book ID: 123325799
Publisher: S. Karger AG
Year: 2013
Tongue: English
Weight: 45 KB
Volume: 13
Category: Article
ISSN: 1424-3903
DOI: 10.1016/j.pan.2013.04.050

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## Abstract BCL‐2 is the prototypic anti‐apoptotic protein involved in the regulation of apoptosis. Overexpression of BCL‐2 is common in pancreatic cancer and confers resistance to the apoptotic effect of chemo‐ and radiotherapy. Although these cellular effects of BCL‐2 are traditionally related to