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P853 - HLA genetic markers of IDDM in Buriat population

✍ Scribed by M. Boldyreva; D. Trofimov; I. Guskova; I. Demidova; A. Zilov; I. Dedov; L. Alexeev

Book ID
116115259
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
139 KB
Volume
47
Category
Article
ISSN
0198-8859

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The association of certain HLA-D alleles with insulin-dependent diabetes mellitus (IDDM) is well known. One hundred and sixty-one non-related diabetic individuals and 142 non-related healthy controls were typed for the HLA DR-DQw-Dw association, using a restriction fragment length polymorphism (RFLP

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The purpose of our study was to examine evidence for the role of a second genetic factor in the susceptibility to IDDM, in addition to that located in the HLA region. To do this, we have studied the joint segregation of HLA and another marker conditional on disease status using the IDDM families of