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P829 - Genetic heterogeneity between type 1a and type 1b insulin-dependent diabetes mellitus: HLA class II and TAP gene analysis

โœ Scribed by Maugendre Didier; Alizadeh Mehdi; Gauthier Anisia; Guilhem Isabelle; Pouillaud Charles; Genetet Bernard; Allannic Hubert; Semana Gilbert


Book ID
116115235
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
167 KB
Volume
47
Category
Article
ISSN
0198-8859

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Both DQA1 and DQB1 genes are implicated
โœ D. A. Cavan; K. H. Jacobs; M. A. Penny; M. A. Kelly; C. Mijovic; D. Jenkins; J. ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer ๐ŸŒ English โš– 663 KB

Inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus is partly determined by HLA genes. It has been suggested that protection from disease may be conferred by HLA-DQB1 genes which encode molecules with aspartate at position 57. We investigated the contributions of HLA-DRB1, DQA1