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HLA-A, B, C and DR antigens in young South African blacks with Type 1 (insulin-dependent) diabetes mellitus

โœ Scribed by M. A. K. Omar; M. G. Hammond; A. C. Asmal


Publisher
Springer
Year
1984
Tongue
English
Weight
346 KB
Volume
26
Category
Article
ISSN
0012-186X

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HLA-D and -DR antigens in genetic analys
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Three groups of patients with insulin-dependent diabetes mellitus, ascertained by different procedures, were investigated for HLA-A, B, C and D antigens (n = 164), and a subset (n = 93) for HLA-DR. Both HLA-D/DR3 and D/DR4 were strongly positively associated and D/DR2 was negatively associated with

Interaction of HLA and immunoglobulin an
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We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 d