HLA antigens and risk factors for nephropathy in Type 1 (insulin-dependent) diabetes mellitus
โ Scribed by C. Walton; N. P. Mallick; S. Oleesky; P. A. Dyer; J. A. Davidson; R. Harris
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 532 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0012-186X
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๐ SIMILAR VOLUMES
In 129 patients with Type 1 (insulin-dependent) diabetes mellitus, 100 healthy control subjects and 91 non-diabetic first degree relatives of Type 1 patients, we investigated variation in serum IgA, IgG and IgM concentrations with sex and HLA-B phenotype. Two patients with onset before the age of 15
We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 d
Three groups of patients with insulin-dependent diabetes mellitus, ascertained by different procedures, were investigated for HLA-A, B, C and D antigens (n = 164), and a subset (n = 93) for HLA-DR. Both HLA-D/DR3 and D/DR4 were strongly positively associated and D/DR2 was negatively associated with