P73 Mitochondrial abnormalities in inclusion body myositis
β Scribed by K. Rygiel; J. Miller; R.W. Taylor; D.M. Turnbull
- Book ID
- 117670391
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 59 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0960-8966
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Inclusion body myositis (IBM) is a sporadic progressive myopathy, which is morphologically characterized by inflammatory cell infiltrates and rimmed vacuoles in muscle fibers. Mitochondrial changes are regularly present with ragged-red fibers showing deficiency of cytochrome c oxidase. In these musc
A patient with inclusion body niyositis was treated with a course of 22 leukocytaphereses combined with prednisone and azathioprine therapy. He improved clinically during an induction phase of frequent cytapheresis, which reduced the circulating levels of T lymphocytes and monocytes and decreased th