Inclusion body myositis (IBM) is a sporadic progressive myopathy, which is morphologically characterized by inflammatory cell infiltrates and rimmed vacuoles in muscle fibers. Mitochondrial changes are regularly present with ragged-red fibers showing deficiency of cytochrome c oxidase. In these musc
Mitochondrial DNA variants in inclusion body myositis
β Scribed by Chee Choy Kok; Adam Boyt; Silvana Gaudieri; Ralph Martins; Valerie Askanas; Marinos Dalakas; Lyn Kiers; Frank Mastaglia; Michael Garlepp
- Book ID
- 117669333
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 274 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0960-8966
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## Abstract Inclusion body myositis, a chronic inflammatory disorder, is the most common cause of myopathy in adults over the age of 50. Diagnosis is based on clinical features and distinctive morphological findings by both light and electron microscopy. The causes of inclusion body myositis are st
A patient with inclusion body niyositis was treated with a course of 22 leukocytaphereses combined with prednisone and azathioprine therapy. He improved clinically during an induction phase of frequent cytapheresis, which reduced the circulating levels of T lymphocytes and monocytes and decreased th