✦ LIBER ✦

p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53

✍ Scribed by Syunji Hayashi; Toshinori Ozaki; Kaori Yoshida; Mitsuchika Hosoda; Satoru Todo; Shin-ichi Akiyama; Akira Nakagawara

Book ID: 116293195
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 345 KB
Volume: 347
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.06.095

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Disruption of the MDM2–p53 interaction s

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

✍ Koster, R; Timmer-Bosscha, H; Bischoff, R; Gietema, J A; de Jong, S 📂 Article 📅 2011 🏛 Nature Publishing Group 🌐 English ⚖ 734 KB

Wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. Although high levels of wild-type p53 and hardly any __TP53__ mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patient

686 Recruitment of histone methyltransfe

686 Recruitment of histone methyltransferases to the p53-MDM2 complex regulates p53 transcriptional output by promoting histone and p53 methylation

✍ A.K. Zwolinska; L. Chen; Z. Li; J. Chen; J.C. Marine 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 48 KB

The oncogenic phosphatase PPM1D confers

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation

✍ Ali, A Y; Abedini, M R; Tsang, B K 📂 Article 📅 2011 🏛 Nature Publishing Group 🌐 English ⚖ 787 KB

SYNERGISTIC ENHANCEMENT OF RESISTANCE TO

SYNERGISTIC ENHANCEMENT OF RESISTANCE TO CISPLATIN IN HUMAN BLADDER CANCER CELLS BY OVEREXPRESSION OF MUTANT-TYPE p53 AND Bcl-2

✍ MIYAKE, HIDEAKI; HARA, ISAO; YAMANAKA, KAZUKI; ARAKAWA, SOICHI; KAMIDONO, SADAO 📂 Article 📅 1999 🏛 Lippincott Williams and Wilkins 🌐 English ⚖ 418 KB

In squamous cell carcinoma of the vulva,

In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases

✍ Emanuels, A G; Koudstaal, J; Burger, M P M; Hollema, H 📂 Article 📅 1999 🏛 Nature Publishing Group 🌐 English ⚖ 296 KB

Multiple lysine mutations in the C-termi

Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells

✍ Nakamura, Seiichi; Roth, Jack A; Mukhopadhyay, Tapas 📂 Article 📅 2002 🏛 Nature Publishing Group 🌐 English ⚖ 223 KB