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SYNERGISTIC ENHANCEMENT OF RESISTANCE TO CISPLATIN IN HUMAN BLADDER CANCER CELLS BY OVEREXPRESSION OF MUTANT-TYPE p53 AND Bcl-2

✍ Scribed by MIYAKE, HIDEAKI; HARA, ISAO; YAMANAKA, KAZUKI; ARAKAWA, SOICHI; KAMIDONO, SADAO

Book ID: 122365739
Publisher: Lippincott Williams and Wilkins
Year: 1999
Tongue: English
Weight: 418 KB
Volume: 162
Category: Article
ISSN: 0022-5347
DOI: 10.1016/S0022-5347(05)68155-4

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## Abstract Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines differing in __p53__ and __bax__ status: p53^−/0^bax^+/+^ for TC7, SW480, HT‐29; p53^+/+^bax^−/−^ for