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p70 S6 kinase limits tumor necrosis factor-α-induced interleukin-6 synthesis in osteoblast-like cells

✍ Scribed by Chiho Minamitani; Haruhiko Tokuda; Seiji Adachi; Rie Matsushima-Nishiwaki; Junichi Yamauchi; Kenji Kato; Hideo Natsume; Jun Mizutani; Osamu Kozawa; Takanobu Otsuka


Book ID
116734681
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
449 KB
Volume
315
Category
Article
ISSN
0303-7207

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## Abstract Inflammatory cytokines are well known to play crucial roles in the pathogenesis of rheumatoid arthritis. Among them, interleukin (IL)‐17 is a cytokine that is mainly synthesized by activated T cells and its receptors are present in osteoblasts. The synthesis of IL‐6, known to stimulate