p63 in epithelial development
β Scribed by E. Candi; R. Cipollone; P. Rivetti di Val Cervo; S. Gonfloni; G. Melino; R. Knight
- Book ID
- 105758796
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 918 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1420-682X
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The p53 homologue p63 is essential for ectodermal differentiation, such that p63Ψ/Ψ mice lack all squamous epithelia and teeth. The p63 gene expresses at least 6 different transcripts, but information regarding the expression, regulation and function of the different isoforms has remained sparse, du
## Abstract The fetal and neonatal development of male germ cells (gonocytes) is a poorly understood but crucial process for establishing fertility. In rodents, gonocytes go through two phases of proliferation accompanied by apoptosis and separated by a quiescent period during the end of fetal deve